Renal Tumors

The 2016 WHO Kidney Tumors added a number of new subtypes with unique cytogenetic abnormalities that can help in diagnosis and differential diagnosis. (1) Acquired Cystic Kidney Disease (ACD)-associated renal cell carcinoma is present with the acquisition of chromosomes 3, 7, 16, 17, and Y. (2) Clear cell papillary renal cell carcinoma is a low-grade malignant rare tumor that morphologically needs to be differentiated from a variety of renal carcinomas with clear cell and papillary structures, including renal clear cell carcinoma, papillary renal cell carcinoma, and Xp11 translocation renal carcinoma; clear cell papillary renal cell carcinoma does not have 3p deletion, mutation of the VHL gene, or chromosome 7 and 17, which is characteristic of renal clear cell carcinoma. chromosome acquisition and Y chromosome deletion in papillary renal carcinoma. In addition, the cytogenetic abnormality in smoky cell renal cell carcinoma is the deletion of chromosome 1/2/6/10/13/17/21, which can be distinguished from eosinophilic renal cell tumor.

Chromosome number and long and short arm testing

Chromosome 17 number testing.