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CCND1(BCL1)/IGH fusion gene t(11;14) probe
Product Code:R-0501213Ⅰ-01/R-0501213Ⅰ-02/R-0501213Ⅱ-01/R-0501213Ⅱ-02/R-0501213Ⅲ-01/R-0501213Ⅲ-02/R-0501213Ⅳ-01/R-0501213Ⅳ-02
Probe name:GSP CCND1 / GSP IGH
Product Code:Type I (direct FISH method)/Type II (biotin-labeled indirect FISH method)/Type III (digoxigenin-labeled indirect FISH method)/Type IV (TSA-FISH method)
Registration Number:
Clinical Value

Lymphoma

Masculine cell lymphoma (MCL) is a subtype of NHL with a poor prognosis;

MCL is diagnosed primarily on the basis of typical histomorphologic features, immunophenotypes and/or t(11;14)/CCND1 abnormalities; typical immunophenotypes are CD5+,CD20+, CD23-/+, CyclinD1+,CD10-/+;

t(11;14) ( q13; q32) occurs in 75% of mantle cell lymphoma (MCL) and can be used to aid in the diagnosis of this tumor;

is used to differentiate MCL from CLL.


Multiple myeloma (MM)

t(11;14) is the most common aberrant translocation in MM;

Aids in the diagnosis of mantle cell lymphoma (MCL).