Breast Cancer

Applied to Mammary-type Myofibroblastoma: a soft-tissue tumor originating in the breast that is indistinguishable from myofibroblastoma;

This tumor is often desmin and CD34 positive, with deletion of RB1 expression in about 90% of the patients; its genetic profile is similar to that of spindle cell lipoma, with heterozygous or pure heterozygous deletion of locus 13q14 (RB1) and sometimes with deletion of 16q. （The genetic profile is similar to that of spindle cell lipoma, with heterozygous or heterozygous deletion of the 13q14 locus (RB1) and sometimes a 16q deletion.

Fibrous Histiocytic Tumor and Neoplastic Lesions

Applied to spindle cell lipoma/pleomorphic lipoma.

Spindle cell lipomas and pleomorphic lipomas share a common genetic profile and often exhibit 16q13-qter deletions, with 13q12 and 13q14-22 deletions also being more common.