Multiple myeloma MM

In MM, chromosome 13q14 deletion is one of the most common chromosomal abnormalities in MM, which mainly involves the deletion of a larger segment from D13S319 to D13S25, specifically localized to 13q14.3 Early studies found that 13q- was an independent poor prognostic factor for MM patients, but in recent years, foreign scholars have found that 13q- is not an independent prognostic factor, and that its prognosis is Poor prognosis is mainly related to the combination of other poor prognostic factors such as 17p-, t(4;14) and t(14;16). The presence of 13q- in most cases is often accompanied by 17p-, 1q+ and/or t(4;14), so the poor prognosis of 13q- is associated with the occurrence of 17p-, 1q+ and/or t(4;14).

Chronic Lymphocytic Leukemia CLL

In CLL, 13q14 deletion is a common chromosomal abnormality in B-cell CLL, and del(13q14) alone has a better prognosis.